The committee approached its charge by focusing on potential uses of toxicogenomics often discussed in the broad toxicology community, with a focus on human health issues and not environmental impact. The committee determined that the applications described in Chapters 4-8 capture much of the often-cited potential value of toxicogenomics. After ...
Introduction. Compound toxicity is one of the major contributors to the high clinical attrition rates of new drug candidates, with lack of safety being the cause of 24% of failures between 2013–2015.1,2 Anticipating the toxicity profile of a new chemical entity in humans is not an easy task, as it is hampered by long experimental durations and …
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